Evidence for the protective effects of curcumin against oxyhemoglobin-induced injury in rat cortical neurons

Highlights • Curcumin protects the cortical neurons from oxyhemoglobin neurotoxicity. • Curcumin attenuates oxidative stress induced by oxyhemoglobin. • Curcumin reduces apoptosis induced by oxyhemoglobin. • Curcumin alleviates inflammation triggered by oxyhemoglobin. • Curcumin has therapeutic pote...

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Veröffentlicht in:	Brain research bulletin 2016-01, Vol.120, p.34-40
Hauptverfasser:	Li, Xia, Zhao, Lei, Yue, Liang, Liu, Haixiao, Yang, Xiangmin, Wang, Xinchuan, Lin, Yan, Qu, Yan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants - metabolism Apoptosis Apoptosis - drug effects Apoptosis - physiology Cell Survival - drug effects Cell Survival - physiology Cells, Cultured Cerebral Cortex - drug effects Cerebral Cortex - pathology Cerebral Cortex - physiopathology Curcuma longa Curcumin Curcumin - pharmacology Disease Models, Animal Dose-Response Relationship, Drug Lipid Peroxidation - drug effects Lipid Peroxidation - physiology Neuroimmunomodulation - drug effects Neuroimmunomodulation - physiology Neurology Neurons - drug effects Neurons - pathology Neurons - physiology Neuroprotective Agents - pharmacology Oxidative Stress - drug effects Oxidative Stress - physiology Oxyhemoglobin Oxyhemoglobins - toxicity Rats, Sprague-Dawley Reactive Oxygen Species - metabolism Subarachnoid hemorrhage Subarachnoid Hemorrhage - drug therapy Subarachnoid Hemorrhage - pathology Subarachnoid Hemorrhage - physiopathology
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Beschreibung
Zusammenfassung:	Highlights • Curcumin protects the cortical neurons from oxyhemoglobin neurotoxicity. • Curcumin attenuates oxidative stress induced by oxyhemoglobin. • Curcumin reduces apoptosis induced by oxyhemoglobin. • Curcumin alleviates inflammation triggered by oxyhemoglobin. • Curcumin has therapeutic potential in the treatment of SAH.
ISSN:	0361-9230 1873-2747
DOI:	10.1016/j.brainresbull.2015.11.006