Cytogenetic study of workers exposed to chromium compounds

The frequency of sister chromatid exchanges (SCEs), high SCE frequency cells (HFCs), and genetic polymorphism of genotypes glutathione S-transferase (GST) M1 and T1 were analyzed in peripheral lymphocytes of 35 workers occupationally exposed to chromium (Cr) and 35 matched control group. Results sho...

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Veröffentlicht in:	Mutation research 2000-01, Vol.464 (2), p.289-296
Hauptverfasser:	Wu, Fang-Yang, Tsai, Fuu-Jen, Kuo, Hsien-Wen, Tsai, Chang-Hai, Wu, Wu-Yui, Wang, Ruey-Yun, Lai, Jim-Shoung
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age Distribution Biological and medical sciences Cells, Cultured Chemical mutagenesis Chromium Compounds - adverse effects Chromium worker Chromosome Aberrations - genetics cytogenetics Diet Environmental Monitoring Female Gene Frequency - genetics Genotype Glutathione Transferase - genetics Glutathione Transferase - metabolism GSTM1 GSTT1 HFC Humans Lymphocytes - cytology Lymphocytes - drug effects Lymphocytes - enzymology Male Medical sciences Occupational Exposure - adverse effects SCE Sex Distribution Sister Chromatid Exchange - drug effects Sister Chromatid Exchange - genetics Smoking - adverse effects Toxicology
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Zusammenfassung:	The frequency of sister chromatid exchanges (SCEs), high SCE frequency cells (HFCs), and genetic polymorphism of genotypes glutathione S-transferase (GST) M1 and T1 were analyzed in peripheral lymphocytes of 35 workers occupationally exposed to chromium (Cr) and 35 matched control group. Results showed that workers exposed to Cr showed 6.07 SCE/cell, as compared to 4.76 SCE/cell for the control group ( p
ISSN:	1383-5718 0027-5107 1879-3592
DOI:	10.1016/S1383-5718(99)00206-5