Structures of Two New 18, 22-Cyclosterols, Emesterones A and B, from Emericella heterothallica

Two new 18, 22-cyclosterols, emesterones A (2) and B (3), were isolated along with Mer-NF8054X (1) from the culture filtrate of Emericella heterothallica. The structures of 2 and 3 were established as 3, 11-dioxo-18, 22-cycloergosta-6, 8(14)-diene-5β, 9β, 23S-triol and 3, 11-dioxo-18, 22-cycloergost...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 1998/05/15, Vol.46(5), pp.850-852
Hauptverfasser:	HOSOE, Tomoo, SAMESHIMA, Tomohiro, DOBASHI, Kazuyuki, KAWAI, Ken-ichi
Format:	Artikel
Sprache:	eng
Schlagworte:	18, 22-cycloergostane antifungal activity Aspergillus fumigatus Biological and medical sciences cyclosterols Emericella heterothallica emesterone A emesterone B General pharmacology Medical sciences Mer-NF8054X Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments
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Zusammenfassung:	Two new 18, 22-cyclosterols, emesterones A (2) and B (3), were isolated along with Mer-NF8054X (1) from the culture filtrate of Emericella heterothallica. The structures of 2 and 3 were established as 3, 11-dioxo-18, 22-cycloergosta-6, 8(14)-diene-5β, 9β, 23S-triol and 3, 11-dioxo-18, 22-cycloergosta-4, 6, 8(14)-triene-9β, 23S-diol, respectively, on the basis of spectroscopic and chemical investigations. The antifungal activity of emesterone B (3) towards Aspergillus fumigatus was slightly weaker than that of Mer-NF8054X (1).
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.46.850