Dose and time dependency of cytochrome P4501A induction in liver and kidney of B(a)P exposed Arctic charr ( Salvelinus alpinus)
The cytochrome P4501A induction was studied in liver and kidney of immature Arctic charr ( Salvelinus alpinus) after exposure to different dosages of benzo(a)pyrene (B(a)P) at low temperatures. Maximum induction was reached at day 5 in both organs, with highest values in the liver. No clear dose-res...
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| Veröffentlicht in: | Marine environmental research 1998-07, Vol.46 (1), p.117-120 |
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| container_title | Marine environmental research |
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| creator | Wolkers, J. Jørgensen, E.H. Nijmeijer, S.M. Witkamp, R.F. |
| description | The cytochrome P4501A induction was studied in liver and kidney of immature Arctic charr (
Salvelinus alpinus) after exposure to different dosages of benzo(a)pyrene (B(a)P) at low temperatures. Maximum induction was reached at day 5 in both organs, with highest values in the liver. No clear dose-response could be observed, possibly due to an extremely sensitive P450 system or a limited B(a)P absorption from the gut. The apparent sensitivity of both organs towards B(a)P exposure can be considered as advantageous for biomonitoring. |
| doi_str_mv | 10.1016/S0141-1136(97)00126-8 |
| format | Article |
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| identifier | ISSN: 0141-1136 |
| ispartof | Marine environmental research, 1998-07, Vol.46 (1), p.117-120 |
| issn | 0141-1136 1879-0291 |
| language | eng |
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| source | Access via ScienceDirect (Elsevier) |
| subjects | Agnatha. Pisces Animal, plant and microbial ecology Applied ecology benzo(a)pyrene Biological and medical sciences cytochrome P4501A Ecotoxicology, biological effects of pollution Effects of pollution and side effects of pesticides on vertebrates Fundamental and applied biological sciences. Psychology Marine Salvelinus alpinus |
| title | Dose and time dependency of cytochrome P4501A induction in liver and kidney of B(a)P exposed Arctic charr ( Salvelinus alpinus) |
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