Dose and time dependency of cytochrome P4501A induction in liver and kidney of B(a)P exposed Arctic charr ( Salvelinus alpinus)

The cytochrome P4501A induction was studied in liver and kidney of immature Arctic charr ( Salvelinus alpinus) after exposure to different dosages of benzo(a)pyrene (B(a)P) at low temperatures. Maximum induction was reached at day 5 in both organs, with highest values in the liver. No clear dose-res...

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Veröffentlicht in:	Marine environmental research 1998-07, Vol.46 (1), p.117-120
Hauptverfasser:	Wolkers, J., Jørgensen, E.H., Nijmeijer, S.M., Witkamp, R.F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Agnatha. Pisces Animal, plant and microbial ecology Applied ecology benzo(a)pyrene Biological and medical sciences cytochrome P4501A Ecotoxicology, biological effects of pollution Effects of pollution and side effects of pesticides on vertebrates Fundamental and applied biological sciences. Psychology Marine Salvelinus alpinus
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Beschreibung
Zusammenfassung:	The cytochrome P4501A induction was studied in liver and kidney of immature Arctic charr ( Salvelinus alpinus) after exposure to different dosages of benzo(a)pyrene (B(a)P) at low temperatures. Maximum induction was reached at day 5 in both organs, with highest values in the liver. No clear dose-response could be observed, possibly due to an extremely sensitive P450 system or a limited B(a)P absorption from the gut. The apparent sensitivity of both organs towards B(a)P exposure can be considered as advantageous for biomonitoring.
ISSN:	0141-1136 1879-0291
DOI:	10.1016/S0141-1136(97)00126-8