Ascaulitoxin, a phytotoxic bis-amino acid N-glucoside from Ascochyta caulina

Ascaulitoxin ( 1), a new unusual phytotoxic bis-amino-acid N-glucoside with potential herbicide activity was isolated from culture filtrates of Ascochyta caulina. Ascaulitoxin, which was characterized as N 2- (2,4,7-triamino-5-hydroxy)-octanedioyl-β- d-glucopyranoside showed a significant phytotoxic activity on host ( Chenopodium album) and non-host plants A new unusual phytotoxic bis-amino acid N-glucoside, named ascaulitoxin, was isolated from the culture filtrate of Ascochyta caulina, the causal agent of leaf and stem necrosis of Chenopodium album, a promising mycoherbicide for the biological control of this common noxious weed. Ascaulitoxin, characterized by extensive use of NMR techniques and chemical methods as N 2- (2,4,7-triamino-5-hydroxy)-octanedioyl-β- d-glucopyranoside , showed phytotoxic activity against host and non-host plants.