T-lymphocyte-epithelial-cell interactions: integrin alpha sub(E)(CD103) beta sub(7), LEEP-CAM and chemokines

The epithelia are the avascular layers of cells that cover the environment-exposed surfaces of the body. It appears that T cells localize to selected sites in or adjacent to epithelia via the selective expression of adhesion molecules and chemokine receptors on T cells. These bind to counter-recepto...

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Veröffentlicht in:Current opinion in cell biology 2000-10, Vol.12 (5), p.563-568
Hauptverfasser: Agace, W W, Higgins, JMG, Sadasivan, B, Brenner, M B, Parker, C M
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Sprache:eng
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Zusammenfassung:The epithelia are the avascular layers of cells that cover the environment-exposed surfaces of the body. It appears that T cells localize to selected sites in or adjacent to epithelia via the selective expression of adhesion molecules and chemokine receptors on T cells. These bind to counter-receptors and to chemokines expressed by epithelial cells. Recently, there has been an advance in our understanding of the interaction of the alpha sub(E) beta sub(7) integrin with its epithelial cell ligand, E-cadherin. In addition, a new adhesion molecule has been identified on non-intestinal epithelial cells, termed lymphocyte-endothelial-epithelial-cell adhesion molecule (LEEP-CAM). Finally, there have been advances in our understanding of the role of skin- or gut-epithelia-derived chemokines in regulating activated T cell homing to these sites.
ISSN:0955-0674
DOI:10.1016/S0955-0674(00)00132-0