Radioprotective effect of Phyllanthus niruri on mouse chromosomes

Radioprotective effect of Phyllanthus niruri on mouse chromosomes

Micronuclei (MN) induction in the mouse bone marrow polychromatic erythrocytes (PCE) and normochromatic erythrocytes (NCE) was studied 24 h after whole body exposure to 4 Gy of gamma radiation with or without a single intraperitoneal injection of 25 mg/kg to 150 mg/kg of 50% methanolic extract of Ph...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Current science (Bangalore) 2000-05, Vol.78 (10), p.1245-1247
Hauptverfasser: Devi, P. Uma, Kamath, Ravindra, Rao, B. S. S.
Format: Artikel
Sprache:eng
Schlagworte:
Bone marrow
Chromosomes
Dosage
Dose response relationship
Erythrocytes
Phyllanthus niruri
Radiation damage
Radiation dosage
Radiation dose response relationship
RESEARCH COMMUNICATIONS
Whole body irradiation
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Micronuclei (MN) induction in the mouse bone marrow polychromatic erythrocytes (PCE) and normochromatic erythrocytes (NCE) was studied 24 h after whole body exposure to 4 Gy of gamma radiation with or without a single intraperitoneal injection of 25 mg/kg to 150 mg/kg of 50% methanolic extract of Phyllanthus niruri (whole aerial part). The extract significantly reduced the radiation-induced MN induction in both PCE and NCE and increased the ratio of PCE to NCE. The effect increased linearly with extract dose from 25 to 125 mg/kg.
ISSN:0011-3891