Optimal method for measuring tumor extent in needle biopsy specimens to identify small-volume prostate cancer

Objectives To compare various methods for measuring tumor extent in prostate biopsy specimens to identify small‐volume prostate cancer. Methods A total of 100 radical prostatectomy specimens were retrospectively analyzed. Receiver operating characteristic analysis was used to compare the abilities o...

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Veröffentlicht in:	International journal of urology 2016-01, Vol.23 (1), p.62-68
Hauptverfasser:	Kajikawa, Keishi, Kanao, Kent, Kobayashi, Ikuo, Nishikawa, Genya, Yoshizawa, Takahiko, Kato, Yoshiharu, Watanabe, Masahito, Zennami, Kenji, Nakamura, Kogenta, Sumitomo, Makoto
Format:	Artikel
Sprache:	eng
Schlagworte:	active surveillance Aged Area Under Curve Endoscopic Ultrasound-Guided Fine Needle Aspiration Humans insignificant cancer Male Middle Aged prostate cancer Prostate-Specific Antigen - blood Prostatectomy Prostatic Neoplasms - blood Prostatic Neoplasms - pathology Prostatic Neoplasms - surgery ROC Curve total length of cancer Tumor Burden tumor extent in biopsy specimens
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Beschreibung
Zusammenfassung:	Objectives To compare various methods for measuring tumor extent in prostate biopsy specimens to identify small‐volume prostate cancer. Methods A total of 100 radical prostatectomy specimens were retrospectively analyzed. Receiver operating characteristic analysis was used to compare the abilities of prostate‐specific antigen density, and four measures of tumor extent in prostate biopsy specimens – positive core number, greatest percentage of cancer in a single core, greatest length of cancer in cores and total length of cancer in cores – to identify small volume prostate cancer. Four definitions of insignificant cancer volume were used in this analysis: index and total tumor volume
ISSN:	0919-8172 1442-2042
DOI:	10.1111/iju.12961