Two‐year outcomes on bone density and fracture incidence in patients with T2DM randomized to bariatric surgery versus intensive medical therapy

Two‐year outcomes on bone density and fracture incidence in patients with T2DM randomized to bariatric surgery versus intensive medical therapy

Objective To determine the 2‐year outcomes of Roux‐en‐Y gastric bypass (RYGB) and sleeve gastrectomy (SG) vs. intensive medical therapy (IMT) on lean body mass, total bone mass, and bone mineral density (BMD) measures from the STAMPEDE trial. Methods 54 subjects (BMI: 36 ± 1 kg/m2, age: 48 ± 4 years...

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Veröffentlicht in:Obesity (Silver Spring, Md.) Md.), 2015-12, Vol.23 (12), p.2344-2348
Hauptverfasser: Maghrabi, Adam H., Wolski, Kathy, Abood, Beth, Licata, Angelo, Pothier, Claire, Bhatt, Deepak L., Nissen, Steven, Brethauer, Stacy A., Kirwan, John P., Schauer, Philip R., Kashyap, Sangeeta R.
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Bariatric Surgery - statistics & numerical data
Body Composition - physiology
Body mass index
Bone Density
Diabetes
Diabetes Mellitus, Type 2 - drug therapy
Diabetes Mellitus, Type 2 - surgery
Diabetes Mellitus, Type 2 - therapy
Female
Follow-Up Studies
Fractures
Fractures, Bone - epidemiology
Gastrointestinal surgery
Humans
Hyperglycemia
Hypoglycemic Agents - administration & dosage
Incidence
Male
Metabolism
Middle Aged
Obesity
Osteoporosis
Studies
Treatment Outcome
Vitamin D
Weight control
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Zusammenfassung:Objective To determine the 2‐year outcomes of Roux‐en‐Y gastric bypass (RYGB) and sleeve gastrectomy (SG) vs. intensive medical therapy (IMT) on lean body mass, total bone mass, and bone mineral density (BMD) measures from the STAMPEDE trial. Methods 54 subjects (BMI: 36 ± 1 kg/m2, age: 48 ± 4 years) with type 2 diabetes (T2DM) (HbA1c: 9.7 ± 2%) were randomized to IMT, RYGB, or SG and underwent DXA at baseline and at 1 and 2 years. Results At 2 years, the reduction in BMI was similar after RYGB and SG and was greater than IMT (P 
ISSN:1930-7381
1930-739X
DOI:10.1002/oby.21150