Prognostic significance of macrophage polarization in early stage oral squamous cell carcinomas

Highlights • M2 macrophage polarization is associated with poor tumor outcome in early stage oral squamous cell carcinomas (oscc). • M2 macrophage polarization in diagnostic biopsies correlates with high tumor grading. • Macrophage polarization in diagnostic biopsies could be a prognostic marker for...

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Veröffentlicht in:	Oral oncology 2016-01, Vol.52, p.75-84
Hauptverfasser:	Weber, Manuel, Iliopoulos, Christos, Moebius, Patrick, Büttner-Herold, Maike, Amann, Kerstin, Ries, Jutta, Preidl, Raimund, Neukam, Friedrich W, Wehrhan, Falk
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, CD - metabolism Antigens, Differentiation, Myelomonocytic - metabolism Biomarkers - metabolism Biopsy Carcinoma, Squamous Cell - pathology CD11c Antigen - metabolism Hematology, Oncology and Palliative Medicine Humans Macrophage polarization Macrophages - pathology Mouth Neoplasms - pathology Oral cancer Oral squamous cell carcinoma Oscc Otolaryngology Pilot Projects Prognosis Receptors, Cell Surface - metabolism Receptors, Immunologic - metabolism TMA Tumor outcome
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Zusammenfassung:	Highlights • M2 macrophage polarization is associated with poor tumor outcome in early stage oral squamous cell carcinomas (oscc). • M2 macrophage polarization in diagnostic biopsies correlates with high tumor grading. • Macrophage polarization in diagnostic biopsies could be a prognostic marker for oscc.
ISSN:	1368-8375 1879-0593
DOI:	10.1016/j.oraloncology.2015.11.001