Highly selective two-photon imaging of cysteine in cancerous cells and tissues
Abnormal concentrations of Cys have been reported to be implicated in various health problems, including cancer, neuropathy, and cardiomyopathy. We present a novel two-photon fluorescent probe for the specific recognition of cysteine over homocysteine and glutathione, and the bioapplication of this...
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| Veröffentlicht in: | Chemical communications (Cambridge, England) England), 2015-10, Vol.51 (76), p.14401-14404 |
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| container_issue | 76 |
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| container_title | Chemical communications (Cambridge, England) |
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| creator | Lee, Yun Hak Ren, Wen Xiu Han, Jiyou Sunwoo, Kyoung Lim, Ja-Yun Kim, Jong-Hoon Kim, Jong Seung |
| description | Abnormal concentrations of Cys have been reported to be implicated in various health problems, including cancer, neuropathy, and cardiomyopathy. We present a novel two-photon fluorescent probe for the specific recognition of cysteine over homocysteine and glutathione, and the bioapplication of this probe for the imaging of live cancerous cells and thick tissues. |
| doi_str_mv | 10.1039/c5cc06038a |
| format | Article |
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We present a novel two-photon fluorescent probe for the specific recognition of cysteine over homocysteine and glutathione, and the bioapplication of this probe for the imaging of live cancerous cells and thick tissues.</description><identifier>ISSN: 1359-7345</identifier><identifier>EISSN: 1364-548X</identifier><identifier>DOI: 10.1039/c5cc06038a</identifier><identifier>PMID: 26271369</identifier><language>eng</language><publisher>England</publisher><subject>Animals ; Cancer ; Cell Line, Tumor ; Cysteine ; Cysteine - analysis ; Fluorescence ; Fluorescent Dyes - chemistry ; Glutathione ; Glutathione - analysis ; Health ; HeLa Cells ; Hep G2 Cells ; Homocysteine - analysis ; Humans ; Imaging ; Mice ; Microscopy, Fluorescence, Multiphoton - methods ; Neoplasms - chemistry ; Neoplasms - pathology ; Optical Imaging - methods ; Recognition ; Spectrometry, Fluorescence</subject><ispartof>Chemical communications (Cambridge, England), 2015-10, Vol.51 (76), p.14401-14404</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c320t-96984dd6bfc4247114d09626c7fd50caa7c2e38a116e2bf9e183684e01300a853</citedby><cites>FETCH-LOGICAL-c320t-96984dd6bfc4247114d09626c7fd50caa7c2e38a116e2bf9e183684e01300a853</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26271369$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Yun Hak</creatorcontrib><creatorcontrib>Ren, Wen Xiu</creatorcontrib><creatorcontrib>Han, Jiyou</creatorcontrib><creatorcontrib>Sunwoo, Kyoung</creatorcontrib><creatorcontrib>Lim, Ja-Yun</creatorcontrib><creatorcontrib>Kim, Jong-Hoon</creatorcontrib><creatorcontrib>Kim, Jong Seung</creatorcontrib><title>Highly selective two-photon imaging of cysteine in cancerous cells and tissues</title><title>Chemical communications (Cambridge, England)</title><addtitle>Chem Commun (Camb)</addtitle><description>Abnormal concentrations of Cys have been reported to be implicated in various health problems, including cancer, neuropathy, and cardiomyopathy. We present a novel two-photon fluorescent probe for the specific recognition of cysteine over homocysteine and glutathione, and the bioapplication of this probe for the imaging of live cancerous cells and thick tissues.</description><subject>Animals</subject><subject>Cancer</subject><subject>Cell Line, Tumor</subject><subject>Cysteine</subject><subject>Cysteine - analysis</subject><subject>Fluorescence</subject><subject>Fluorescent Dyes - chemistry</subject><subject>Glutathione</subject><subject>Glutathione - analysis</subject><subject>Health</subject><subject>HeLa Cells</subject><subject>Hep G2 Cells</subject><subject>Homocysteine - analysis</subject><subject>Humans</subject><subject>Imaging</subject><subject>Mice</subject><subject>Microscopy, Fluorescence, Multiphoton - methods</subject><subject>Neoplasms - chemistry</subject><subject>Neoplasms - pathology</subject><subject>Optical Imaging - methods</subject><subject>Recognition</subject><subject>Spectrometry, Fluorescence</subject><issn>1359-7345</issn><issn>1364-548X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE1PwzAMhiMEYmNw4QegHBFSIW4-mhynajCkCS4gcauy1N2CunY0HWj_nowNzvhiHx69th9CLoHdAuPmzknnmGJc2yMyBK5EIoV-O97N0iQZF3JAzkJ4Z7FA6lMySFWaRdAMydPUL5b1lgas0fX-E2n_1SbrZdu3DfUru_DNgrYVddvQo2-Q-oY62zjs2k2gDus6UNuUtPchbDCck5PK1gEvDn1EXu8nL_k0mT0_PObjWeJ4yvrEKKNFWap55UQqMgBRMqNS5bKqlMxZm7kU4z8ACtN5ZRA0V1ogA86Y1ZKPyPU-d921H3FvX6x82F1jG4yHFZBJLpnR7D8ogBRSQxbRmz3qujaEDqti3UUH3bYAVuxUF7nM8x_V4whfHXI38xWWf-ivW_4NiQ94TA</recordid><startdate>20151001</startdate><enddate>20151001</enddate><creator>Lee, Yun Hak</creator><creator>Ren, Wen Xiu</creator><creator>Han, Jiyou</creator><creator>Sunwoo, Kyoung</creator><creator>Lim, Ja-Yun</creator><creator>Kim, Jong-Hoon</creator><creator>Kim, Jong Seung</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope></search><sort><creationdate>20151001</creationdate><title>Highly selective two-photon imaging of cysteine in cancerous cells and tissues</title><author>Lee, Yun Hak ; 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| fulltext | fulltext |
| identifier | ISSN: 1359-7345 |
| ispartof | Chemical communications (Cambridge, England), 2015-10, Vol.51 (76), p.14401-14404 |
| issn | 1359-7345 1364-548X |
| language | eng |
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| source | MEDLINE; Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Animals Cancer Cell Line, Tumor Cysteine Cysteine - analysis Fluorescence Fluorescent Dyes - chemistry Glutathione Glutathione - analysis Health HeLa Cells Hep G2 Cells Homocysteine - analysis Humans Imaging Mice Microscopy, Fluorescence, Multiphoton - methods Neoplasms - chemistry Neoplasms - pathology Optical Imaging - methods Recognition Spectrometry, Fluorescence |
| title | Highly selective two-photon imaging of cysteine in cancerous cells and tissues |
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