Highly selective two-photon imaging of cysteine in cancerous cells and tissues

Abnormal concentrations of Cys have been reported to be implicated in various health problems, including cancer, neuropathy, and cardiomyopathy. We present a novel two-photon fluorescent probe for the specific recognition of cysteine over homocysteine and glutathione, and the bioapplication of this...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2015-10, Vol.51 (76), p.14401-14404
Hauptverfasser:	Lee, Yun Hak, Ren, Wen Xiu, Han, Jiyou, Sunwoo, Kyoung, Lim, Ja-Yun, Kim, Jong-Hoon, Kim, Jong Seung
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cancer Cell Line, Tumor Cysteine Cysteine - analysis Fluorescence Fluorescent Dyes - chemistry Glutathione Glutathione - analysis Health HeLa Cells Hep G2 Cells Homocysteine - analysis Humans Imaging Mice Microscopy, Fluorescence, Multiphoton - methods Neoplasms - chemistry Neoplasms - pathology Optical Imaging - methods Recognition Spectrometry, Fluorescence
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Beschreibung
Zusammenfassung:	Abnormal concentrations of Cys have been reported to be implicated in various health problems, including cancer, neuropathy, and cardiomyopathy. We present a novel two-photon fluorescent probe for the specific recognition of cysteine over homocysteine and glutathione, and the bioapplication of this probe for the imaging of live cancerous cells and thick tissues.
ISSN:	1359-7345 1364-548X
DOI:	10.1039/c5cc06038a