Evaluation of DNA methyltransferase activity and inhibition viachiroplasmonic assemblies of gold nanoparticles

Evaluation of DNA methyltransferase activity and inhibition viachiroplasmonic assemblies of gold nanoparticles

Circular dichroism spectroscopy has been explored for detection of methyltransferase activity and inhibition based on DNA-induced chiroplasmonic assemblies of gold nanoparticles and endonuclease HpaII. Good accuracy, precision and sensitivity are obtained in complex matrices such as human serum samp...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2015-09, Vol.51 (76), p.14350-14353
Hauptverfasser: Liu, Yuanjian, Wei, Min, Zhang, Linqun, Wei, Wei, Zhang, Yuanjian, Liu, Songqin
Format: Artikel
Sprache:eng
Schlagworte:
Assemblies
Deoxyribonucleic acid
Dichroism
Gold
Human
Inhibition
Nanoparticles
Serums
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Beschreibung
Zusammenfassung:Circular dichroism spectroscopy has been explored for detection of methyltransferase activity and inhibition based on DNA-induced chiroplasmonic assemblies of gold nanoparticles and endonuclease HpaII. Good accuracy, precision and sensitivity are obtained in complex matrices such as human serum samples, which is significant for clinical diagnosis and drug development.
ISSN:1359-7345
1364-548X
DOI:10.1039/c5cc05375g