Bis(2,2,2-trifluoroethyl) Carbonate as a Condensing Agent in One-Pot Parallel Synthesis of Unsymmetrical Aliphatic Ureas
One-pot parallel synthesis of unsymmetrical aliphatic ureas was achieved with bis(2,2,2-trifluoroethyl) carbonate. The procedure worked well for both the monosubstituted and functionalized alkyl amines and required no special conditions (temperature control, order, or rate of addition). A library of...
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| Veröffentlicht in: | ACS combinatorial science 2014-06, Vol.16 (6), p.303-308 |
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| container_title | ACS combinatorial science |
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| creator | Bogolubsky, Andrey V Moroz, Yurii S Mykhailiuk, Pavel K Granat, Dmitry S Pipko, Sergey E Konovets, Anzhelika I Doroschuk, Roman Tolmachev, Andrey |
| description | One-pot parallel synthesis of unsymmetrical aliphatic ureas was achieved with bis(2,2,2-trifluoroethyl) carbonate. The procedure worked well for both the monosubstituted and functionalized alkyl amines and required no special conditions (temperature control, order, or rate of addition). A library of 96 diverse ureas was easily synthesized. |
| doi_str_mv | 10.1021/co500025f |
| format | Article |
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A library of 96 diverse ureas was easily synthesized.</description><subject>Aliphatic compounds</subject><subject>Amines</subject><subject>Carbonates</subject><subject>Combinatorial analysis</subject><subject>Condensing</subject><subject>Esters - chemistry</subject><subject>Libraries</subject><subject>Molecular Structure</subject><subject>Synthesis</subject><subject>Urea - analogs & derivatives</subject><subject>Urea - chemical synthesis</subject><subject>Urea - chemistry</subject><subject>Ureas</subject><issn>2156-8952</issn><issn>2156-8944</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0U9r2zAYBnBRVpqS9dAvUHQptDCvkizJ8jEL3R8otNDmbGT7VaMiS5kkw_Lt65A0p8Gm96D38OM5vA9Cl5R8pYTRuy4IQggT5gSdMypkoWrOPx13wWboIqW3yRDOaybJGZoxLuuyFtU5-vPNphv2ZZoiR2vcGGKAvN66W7zUsQ1eZ8A6YY2Xwffgk_WvePEKPmPr8aOH4ilk_KSjdg4cft76vIZkEw4Gr3zaDgNMuZ12eOHsZq2z7fAqgk6f0anRLsHF4Z-j1ff7l-XP4uHxx6_l4qHQnFe56CswCpRoW0JLQaqei95QBsyIUlUt4VJLUKSGTilaEVkrKVrZ09qwjksw5Rzd7HM3MfweIeVmsKkD57SHMKaGVmKXy0r5bypELQURXP0HLTmX0ysnerunXQwpRTDNJtpBx21DSbNrsDk2ONmrQ-zYDtAf5UdfE7jeA92l5i2M0U-3-0vQO5zYn_0</recordid><startdate>20140609</startdate><enddate>20140609</enddate><creator>Bogolubsky, Andrey V</creator><creator>Moroz, Yurii S</creator><creator>Mykhailiuk, Pavel K</creator><creator>Granat, Dmitry S</creator><creator>Pipko, Sergey E</creator><creator>Konovets, Anzhelika I</creator><creator>Doroschuk, Roman</creator><creator>Tolmachev, Andrey</creator><general>American Chemical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7U5</scope><scope>8FD</scope><scope>L7M</scope><scope>7SR</scope><scope>8BQ</scope><scope>JG9</scope></search><sort><creationdate>20140609</creationdate><title>Bis(2,2,2-trifluoroethyl) Carbonate as a Condensing Agent in One-Pot Parallel Synthesis of Unsymmetrical Aliphatic Ureas</title><author>Bogolubsky, Andrey V ; Moroz, Yurii S ; Mykhailiuk, Pavel K ; Granat, Dmitry S ; Pipko, Sergey E ; Konovets, Anzhelika I ; Doroschuk, Roman ; Tolmachev, Andrey</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a447t-d7ef8e85bb013507d45df12e2f5387b046a6e809ec8817069865b6d19f2c46ef3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Aliphatic compounds</topic><topic>Amines</topic><topic>Carbonates</topic><topic>Combinatorial analysis</topic><topic>Condensing</topic><topic>Esters - chemistry</topic><topic>Libraries</topic><topic>Molecular Structure</topic><topic>Synthesis</topic><topic>Urea - analogs & derivatives</topic><topic>Urea - chemical synthesis</topic><topic>Urea - chemistry</topic><topic>Ureas</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bogolubsky, Andrey V</creatorcontrib><creatorcontrib>Moroz, Yurii S</creatorcontrib><creatorcontrib>Mykhailiuk, Pavel K</creatorcontrib><creatorcontrib>Granat, Dmitry S</creatorcontrib><creatorcontrib>Pipko, Sergey E</creatorcontrib><creatorcontrib>Konovets, Anzhelika I</creatorcontrib><creatorcontrib>Doroschuk, Roman</creatorcontrib><creatorcontrib>Tolmachev, Andrey</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Materials Research Database</collection><jtitle>ACS combinatorial science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bogolubsky, Andrey V</au><au>Moroz, Yurii S</au><au>Mykhailiuk, Pavel K</au><au>Granat, Dmitry S</au><au>Pipko, Sergey E</au><au>Konovets, Anzhelika I</au><au>Doroschuk, Roman</au><au>Tolmachev, Andrey</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bis(2,2,2-trifluoroethyl) Carbonate as a Condensing Agent in One-Pot Parallel Synthesis of Unsymmetrical Aliphatic Ureas</atitle><jtitle>ACS combinatorial science</jtitle><addtitle>ACS Comb. 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| ispartof | ACS combinatorial science, 2014-06, Vol.16 (6), p.303-308 |
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| language | eng |
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| source | ACS Publications; MEDLINE |
| subjects | Aliphatic compounds Amines Carbonates Combinatorial analysis Condensing Esters - chemistry Libraries Molecular Structure Synthesis Urea - analogs & derivatives Urea - chemical synthesis Urea - chemistry Ureas |
| title | Bis(2,2,2-trifluoroethyl) Carbonate as a Condensing Agent in One-Pot Parallel Synthesis of Unsymmetrical Aliphatic Ureas |
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