Bis(2,2,2-trifluoroethyl) Carbonate as a Condensing Agent in One-Pot Parallel Synthesis of Unsymmetrical Aliphatic Ureas

Bis(2,2,2-trifluoroethyl) Carbonate as a Condensing Agent in One-Pot Parallel Synthesis of Unsymmetrical Aliphatic Ureas

One-pot parallel synthesis of unsymmetrical aliphatic ureas was achieved with bis(2,2,2-trifluoroethyl) carbonate. The procedure worked well for both the monosubstituted and functionalized alkyl amines and required no special conditions (temperature control, order, or rate of addition). A library of...

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Veröffentlicht in:ACS combinatorial science 2014-06, Vol.16 (6), p.303-308
Hauptverfasser: Bogolubsky, Andrey V, Moroz, Yurii S, Mykhailiuk, Pavel K, Granat, Dmitry S, Pipko, Sergey E, Konovets, Anzhelika I, Doroschuk, Roman, Tolmachev, Andrey
Format: Artikel
Sprache:eng
Schlagworte:
Aliphatic compounds
Amines
Carbonates
Combinatorial analysis
Condensing
Esters - chemistry
Libraries
Molecular Structure
Synthesis
Urea - analogs & derivatives
Urea - chemical synthesis
Urea - chemistry
Ureas
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Zusammenfassung:One-pot parallel synthesis of unsymmetrical aliphatic ureas was achieved with bis(2,2,2-trifluoroethyl) carbonate. The procedure worked well for both the monosubstituted and functionalized alkyl amines and required no special conditions (temperature control, order, or rate of addition). A library of 96 diverse ureas was easily synthesized.
ISSN:2156-8952
2156-8944
DOI:10.1021/co500025f