Practical Way to Imidazo[4,5-b] and [4,5-c]Pyridine-2-ones via Cascade Ureidation/Palladium-Catalyzed Cyclization

Practical Way to Imidazo[4,5-b] and [4,5-c]Pyridine-2-ones via Cascade Ureidation/Palladium-Catalyzed Cyclization

We developed an efficient one-pot tandem carbamoyl chloride amination and palladium-catalyzed intramolecular urea cyclization, which furnished high-throughput access to imidazo[4,5-b]pyridine-2-one and related imidazo[4,5-c]pyridine-2-one ring systems. Moderate to excellent yields were reported.

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Veröffentlicht in:ACS combinatorial science 2012-09, Vol.14 (9), p.491-495
Hauptverfasser: Lach, Franck, Koza, Patrice
Format: Artikel
Sprache:eng
Schlagworte:
Amination
Cascades
Catalysis
Chlorides
Combinatorial analysis
Cyclization
Imidazoles - chemical synthesis
Imidazoles - chemistry
Palladium - chemistry
Pyridines - chemical synthesis
Pyridines - chemistry
Urea - chemistry
Ureas
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Zusammenfassung:We developed an efficient one-pot tandem carbamoyl chloride amination and palladium-catalyzed intramolecular urea cyclization, which furnished high-throughput access to imidazo[4,5-b]pyridine-2-one and related imidazo[4,5-c]pyridine-2-one ring systems. Moderate to excellent yields were reported.
ISSN:2156-8952
2156-8944
DOI:10.1021/co300078f