Dual Catalysis for the Redox Annulation of Nitroalkynes with Indoles: Enantioselective Construction of Indolin-3-ones Bearing Quaternary Stereocenters

The enantioselective redox annulation of nitroalkynes with indoles is enabled by gold/chiral phosphoric acid dual catalysis. A range of indolin‐3‐one derivatives bearing quaternary stereocenters at the C2 position were afforded in good yields and excellent enantioselectivities (up to 96 % ee) from readily available starting materials. Two are better than one: An enantioselective redox annulation of nitroalkynes with indoles is enabled by gold/chiral phosphoric acid (CPA) dual catalysis. A range of indolin‐3‐one derivatives bearing quaternary stereocenters at the C2 positions were thus obtained in good yields and excellent enantioselectivities (up to 96 % ee).