Pineal arylalkylamine N-acetyltransferase (Aanat) gene expression as a target of inflammatory mediators in the chicken

Highlights ► The effect of peritonitis on the chicken pineal melatonin biosynthesis was measured. ► Inflammation caused a decrease in the chicken pineal level of the Aanat mRNA. ► Pineal Aanat gene is a target for inflammatory mediators in the chickens. ► Pineal AANAT protein content and enzymatic a...

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Veröffentlicht in:	General and comparative endocrinology 2012-11, Vol.179 (2), p.143-151
Hauptverfasser:	Piesiewicz, Aneta, Kedzierska, Urszula, Adamska, Iwona, Usarek, Michal, Zeman, Michal, Skwarlo-Sonta, Krystyna, Majewski, Pawel Marek
Format:	Artikel
Sprache:	eng
Schlagworte:	AANAT acetylserotonin O-methyltransferase Acetylserotonin O-Methyltransferase - biosynthesis Animals Arylalkylamine N-Acetyltransferase - biosynthesis Arylalkylamine N-Acetyltransferase - genetics biochemical pathways biosynthesis blood serum Chickens Chickens - metabolism Circadian Rhythm - physiology dihydroxyphenylalanine Dopa Decarboxylase - biosynthesis Down-Regulation endocrinology Endocrinology & Metabolism gene expression gene expression regulation genes immune system Inflammation Inflammation Mediators - physiology Male melatonin Melatonin - biosynthesis messenger RNA peritonitis Peritonitis - chemically induced Peritonitis - physiopathology photophase pineal body Pineal gland Pineal Gland - drug effects Pineal Gland - enzymology quantitative polymerase chain reaction RNA, Messenger - metabolism Serotonin - analogs & derivatives Serotonin - metabolism Thioglycolates transcription (genetics) tryptophan Tryptophan Hydroxylase - biosynthesis
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Zusammenfassung:	Highlights ► The effect of peritonitis on the chicken pineal melatonin biosynthesis was measured. ► Inflammation caused a decrease in the chicken pineal level of the Aanat mRNA. ► Pineal Aanat gene is a target for inflammatory mediators in the chickens. ► Pineal AANAT protein content and enzymatic activity is lower during peritonitis. ► Inflammatory mediators act at the level of the pineal Aanat gene transcription.
ISSN:	0016-6480 1095-6840
DOI:	10.1016/j.ygcen.2012.08.013