Infectious asthma triggers: time to revise the hygiene hypothesis?

Infectious asthma triggers: time to revise the hygiene hypothesis?

The hygiene hypothesis supports an inverse relationship between respiratory infections in early-life and atopic diseases. However, a recent study supports growing evidence that early-life infection and airway microbiome composition can significantly influence asthma inception and exacerbation later...

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Veröffentlicht in:Trends in microbiology (Regular ed.) 2015-07, Vol.23 (7), p.389-391
Hauptverfasser: Webley, Wilmore C, Aldridge, Kelly L
Format: Artikel
Sprache:eng
Schlagworte:
asthma
Asthma - epidemiology
Humans
hygiene hypothesis
Internal Medicine
microbiome
Microbiota
Nasopharynx - microbiology
Nasopharynx - virology
respiratory infection
Respiratory Tract Infections - pathology
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Zusammenfassung:The hygiene hypothesis supports an inverse relationship between respiratory infections in early-life and atopic diseases. However, a recent study supports growing evidence that early-life infection and airway microbiome composition can significantly influence asthma inception and exacerbation later in life. This reignites discussions on infection-mediated asthma phenotypes and potential therapeutics.
ISSN:0966-842X
1878-4380
DOI:10.1016/j.tim.2015.05.006