The LIM Homeobox Gene ceh-14 Confers Thermosensory Function to the AFD Neurons in Caenorhabditis elegans

In Caenorhabditis elegans three pairs of neurons, AFD, AIY, and AIZ, play a key role in thermosensation. The LIM homeobox gene ceh-14 is expressed in the AFD thermosensory neurons. ceh-14 mutant animals display athermotactic behaviors, although the neurons are still present and differentiated. Two o...

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Veröffentlicht in:	Neuron (Cambridge, Mass.) Mass.), 2000-03, Vol.25 (3), p.587-597
Hauptverfasser:	Cassata, Giuseppe, Kagoshima, Hiroshi, Andachi, Yoshiki, Kohara, Yuji, Dürrenberger, Markus B., Hall, David H., Bürglin, Thomas R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Animals, Genetically Modified Behavior, Animal - physiology Body Temperature Regulation - genetics Caenorhabditis elegans Caenorhabditis elegans - genetics Caenorhabditis elegans Proteins ceh-14 gene chemosensation Gene Deletion Gene Expression - physiology Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Hot Temperature Interneurons - physiology LIM protein LIM-Homeodomain Proteins lin-11 gene Molecular Sequence Data Motor Neurons - physiology Movement - physiology Mutagenesis - physiology Neurons, Afferent - chemistry Neurons, Afferent - physiology Neuropeptides - genetics Transcription Factors ttx-3 gene
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Zusammenfassung:	In Caenorhabditis elegans three pairs of neurons, AFD, AIY, and AIZ, play a key role in thermosensation. The LIM homeobox gene ceh-14 is expressed in the AFD thermosensory neurons. ceh-14 mutant animals display athermotactic behaviors, although the neurons are still present and differentiated. Two other LIM homeobox genes, ttx-3 and lin-11, function in the two interneurons AIY and AIZ, respectively. Thus, the three key thermosensory neurons are specified by three different LIM homeobox genes. ceh-14 ttx-3 lin-11 triple mutant animals have a basic cryophilic thermotaxis behavior indicative of a second thermotaxis pathway. Misexpression of ceh-14 in chemosensory neurons can restore thermotactic behavior without impairing the chemosensory function. Thus, ceh-14 confers thermosensory function to neurons.
ISSN:	0896-6273 1097-4199
DOI:	10.1016/S0896-6273(00)81062-4