Nanovacuums: Nanoparticle Uptake and Differential Cellular Migration on a Carpet of Nanoparticles

The behavior of prostate carcinoma (PC3) cells and human dermal fibroblast (HDF) cells when incubated with sedimented Au NPs in vitro is studied. Darkfield microscopy demonstrates that both PC3 and HDF cells can “vacuum” Au NPs from the surface. Mean square displacement and mean cumulative square di...

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Veröffentlicht in:	Nano letters 2013-05, Vol.13 (5), p.2295-2302
Hauptverfasser:	Yang, Jie An, Phan, Hoa Tri, Vaidya, Shruti, Murphy, Catherine J
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line, Tumor Cell Movement Condensed matter: structure, mechanical and thermal properties Cross-disciplinary physics: materials science rheology Diffusion in nanoscale solids Diffusion in solids Exact sciences and technology Fibroblasts Fibroblasts - chemistry Fibroblasts - cytology Gold - chemistry Gold - pharmacokinetics Human behavior Humans Materials science Metal Nanoparticles - chemistry Microscopy Migration Nanocrystalline materials Nanoparticles Nanoscale materials and structures: fabrication and characterization Nanostructure Physics Surface charge Surface Properties Transport properties of condensed matter (nonelectronic) Uptakes
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Beschreibung
Zusammenfassung:	The behavior of prostate carcinoma (PC3) cells and human dermal fibroblast (HDF) cells when incubated with sedimented Au NPs in vitro is studied. Darkfield microscopy demonstrates that both PC3 and HDF cells can “vacuum” Au NPs from the surface. Mean square displacement and mean cumulative square distance of cells shows that PC3 migration decreases in the presence of Au NPs while for HDF, migration is dependent on the surface charge and shape of Au NPs.
ISSN:	1530-6984 1530-6992
DOI:	10.1021/nl400972r