Effects of tamoxifen on autosomal genes regulating ovary maintenance in adult mice

Environmental endocrine-disrupting chemicals (EDCs), known to bind to estrogen/androgen receptors and mimic native estrogens, have been implicated as a main source for increasing human reproductive and developmental deficiencies and diseases. Tamoxifen (TAM) is one of the most well-known antiestroge...

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Veröffentlicht in:	Environmental science and pollution research international 2015-12, Vol.22 (24), p.20234-20244
Hauptverfasser:	Yu, Mingxi, Liu, Wei, Wang, Jingyun, Qin, Junwen, Wang, Yongan, Wang, Yu
Format:	Artikel
Sprache:	eng
Schlagworte:	17β-Estradiol adults adverse effects Androgen receptors animal ovaries Animals Antiestrogens Aquatic Pollution Atmospheric Protection/Air Quality Control/Air Pollution CD31 antigen cell adhesion Cell adhesion & migration Cell adhesion molecules Cell differentiation Earth and Environmental Science Ecotoxicology Endocrine disruptors Endocrine Disruptors - metabolism Endocrine Disruptors - toxicity endocrine-disrupting chemicals Endothelial cells Environment Environmental Chemistry Environmental Health Environmental science estradiol Estrogens Estrogens - blood Estrogens - genetics FDA approval Female females Fibroblast Growth Factor 9 - blood Fibroblast Growth Factor 9 - genetics Fibroblast growth factor receptor 9 fibroblast growth factors Fibroblasts Follicle Stimulating Hormone - blood Follicle Stimulating Hormone - genetics Forkhead protein Gene expression gene expression regulation Gene Expression Regulation - drug effects Gene regulation Genes Genotype & phenotype Growth factors Humans Laboratory animals Luteinizing hormone Luteinizing Hormone - blood Luteinizing Hormone - genetics Mammals mechanism of action messenger RNA Mice Mice, Inbred ICR ovarian development Ovaries Ovary - drug effects Ovary - metabolism phenotype Phenotypes Progesterone protein synthesis Proteins Reproductive system Reptiles & amphibians Research Article RNA, Messenger - genetics RNA, Messenger - metabolism Sox9 protein SOX9 Transcription Factor - genetics SOX9 Transcription Factor - metabolism Tamoxifen Tamoxifen - metabolism Tamoxifen - toxicity Testis-determining factor Testosterone Transcription factors Up-regulation Waste Water Technology Water Management Water Pollution Control Wnt protein
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