Effects of tamoxifen on autosomal genes regulating ovary maintenance in adult mice

Environmental endocrine-disrupting chemicals (EDCs), known to bind to estrogen/androgen receptors and mimic native estrogens, have been implicated as a main source for increasing human reproductive and developmental deficiencies and diseases. Tamoxifen (TAM) is one of the most well-known antiestroge...

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Veröffentlicht in:Environmental science and pollution research international 2015-12, Vol.22 (24), p.20234-20244
Hauptverfasser: Yu, Mingxi, Liu, Wei, Wang, Jingyun, Qin, Junwen, Wang, Yongan, Wang, Yu
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Sprache:eng
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Zusammenfassung:Environmental endocrine-disrupting chemicals (EDCs), known to bind to estrogen/androgen receptors and mimic native estrogens, have been implicated as a main source for increasing human reproductive and developmental deficiencies and diseases. Tamoxifen (TAM) is one of the most well-known antiestrogens with defined adverse effects on the female reproductive tract, but the mechanisms related to autosomal gene regulation governing ovary maintenance in mammals remain unclear. The expression pattern and levels of key genes and proteins involved in maintaining the ovarian phenotype in mice were analyzed. The results showed that TAM induced significant upregulation of Sox9, which is the testis-determining factor gene. The results showed that TAM induced significant upregulation of Sox9, the testis-determining factor gene, and the expression level of Sox9 mRNA in the ovaries of mice exposed to 75 or 225 mg/kg bw TAM was 2- and 10-fold that in the control group, respectively (p 
ISSN:0944-1344
1614-7499
DOI:10.1007/s11356-015-5245-5