NADPH oxidase 2-derived reactive oxygen species in the hippocampus might contribute to microglial activation in postoperative cognitive dysfunction in aged mice

Highlights • Anesthesia and surgery induced hippocampus-dependent memory impairments in aged mice. • Anesthesia and surgery induced microglial activation and subsequent neuroinflammation and down-regulation of BDNF expression. • Surgery-induced microglial activation was associated with Nox2 activati...

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Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2016-01, Vol.51, p.109-118
Hauptverfasser:	Qiu, Li-Li, Ji, Mu-Huo, Zhang, Hui, Yang, Jiao-Jiao, Sun, Xiao-Ru, Tang, Hui, Wang, Jing, Liu, Wen-Xue, Yang, Jian-Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetophenones - administration & dosage Allergy and Immunology Animals Apocynin Brain-Derived Neurotrophic Factor - metabolism Cognitive dysfunction Conditioning, Classical - drug effects Conditioning, Classical - physiology Encephalitis - complications Encephalitis - enzymology Enzyme Inhibitors - administration & dosage Fear - drug effects Fear - physiology Hippocampus - drug effects Hippocampus - enzymology IL-1β Laparotomy Male Membrane Glycoproteins - antagonists & inhibitors Membrane Glycoproteins - metabolism Memory Disorders - enzymology Memory Disorders - etiology Mice Mice, Inbred C57BL Microglia Microglia - drug effects Microglia - enzymology Motor Activity - drug effects NADPH Oxidase 2 NADPH Oxidases - antagonists & inhibitors NADPH Oxidases - metabolism Nox2 Postoperative Complications - enzymology Postoperative Complications - psychology Prefrontal Cortex - drug effects Prefrontal Cortex - enzymology Psychiatry Reactive Oxygen Species - metabolism Surgery
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Beschreibung
Zusammenfassung:	Highlights • Anesthesia and surgery induced hippocampus-dependent memory impairments in aged mice. • Anesthesia and surgery induced microglial activation and subsequent neuroinflammation and down-regulation of BDNF expression. • Surgery-induced microglial activation was associated with Nox2 activation.
ISSN:	0889-1591 1090-2139
DOI:	10.1016/j.bbi.2015.08.002