Rhododenol-induced leukoderma in a mouse model mimicking Japanese skin

Highlights • We successfully developed a mouse model of Rhododenol-induced leukoderma. • Histological examination indicated a loss of epidermal melanocytes at Day 7. • The melanocyte number did not decrease in albino mice without tyrosinase activity. • Biochemical analyses showed that metabolites of...

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Veröffentlicht in:	Journal of dermatological science 2016-01, Vol.81 (1), p.35-43
Hauptverfasser:	Abe, Yuko, Okamura, Ken, Kawaguchi, Masakazu, Hozumi, Yutaka, Aoki, Hitomi, Kunisada, Takahiro, Ito, Shosuke, Wakamatsu, Kazumasa, Matsunaga, Kayoko, Suzuki, Tamio
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Topical Animals Asian Continental Ancestry Group Autophagy - drug effects Butanols - administration & dosage Butanols - pharmacology Cell Count Cytotoxicity Depigmentaion Dermatology Disease Models, Animal Endoplasmic Reticulum Stress - drug effects Enzyme Inhibitors - administration & dosage Enzyme Inhibitors - pharmacology Epidermal Cells Epidermis - drug effects Epidermis - metabolism Heat-Shock Proteins - metabolism Humans MART-1 Antigen - metabolism Melanins - metabolism Melanocytes - cytology Melanocytes - drug effects Melanocytes - metabolism Mice Mice, Hairless Mice, Inbred C57BL Mice, Transgenic Models, Animal Monophenol Monooxygenase - antagonists & inhibitors Mouse model Rhododendrol Skin Lightening Preparations - administration & dosage Skin Lightening Preparations - pharmacology Skin Pigmentation - drug effects Skin Pigmentation - physiology Tyrosinase Vitiligo - etiology
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Zusammenfassung:	Highlights • We successfully developed a mouse model of Rhododenol-induced leukoderma. • Histological examination indicated a loss of epidermal melanocytes at Day 7. • The melanocyte number did not decrease in albino mice without tyrosinase activity. • Biochemical analyses showed that metabolites of Rhododenol-quinone. • Electron microscopic analyses revealed autophagy and ER expansion in the melanocyte.
ISSN:	0923-1811 1873-569X
DOI:	10.1016/j.jdermsci.2015.10.011