Vitiligo: How do oxidative stress-induced autoantigens trigger autoimmunity?

Highlights • The panorama of the entire procedure in vitiligo (the consecutive occurrences of oxidative stress, damaged melanocytes, autoantigens, autoimmunity and melanocyte destruction) is specifically displayed based on published studies • The comprehensive causes of the overproduction of reactive oxygen species are summarized. • The damage to melanocytes due to oxidative stress and the production of subsequent autoantigens is illuminated in detail. • The specific mechanisms of how autoantigens trigger autoimmunity in vitiligo is demonstrated.