Lack of DNA-damaging activity of five non-nutritive sweeteners in the rat hepatocyte/DNA repair assay

The non-nutritive sweeteners acesulfame-K, aspartame, cyclamate, saccharin and sucralose were tested for DNA damaging activity in the rat hepatocyte/DNA repair assay. Using hepatocytes from F344 and Sprague–Dawley male rats, all were inactive despite strong responses for the positive control, 2-amin...

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Veröffentlicht in:	Food and chemical toxicology 2000-04, Vol.38 (4), p.335-338
Hauptverfasser:	Jeffrey, A.M, Williams, G.M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals aspartame Biological and medical sciences cyclamate DNA - biosynthesis DNA - drug effects DNA damage DNA Repair Food toxicology genotoxic hepatocytes Liver - drug effects Liver - metabolism Male Medical sciences Mutagenicity Tests Rats Rats, Inbred F344 Rats, Sprague-Dawley sweeteners Sweetening Agents - toxicity Toxicology unscheduled DNA synthesis
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Zusammenfassung:	The non-nutritive sweeteners acesulfame-K, aspartame, cyclamate, saccharin and sucralose were tested for DNA damaging activity in the rat hepatocyte/DNA repair assay. Using hepatocytes from F344 and Sprague–Dawley male rats, all were inactive despite strong responses for the positive control, 2-aminofluorene.
ISSN:	0278-6915 1873-6351
DOI:	10.1016/S0278-6915(99)00163-5