Treatment of HER2 positive advanced breast cancer with T-DM1: A review of the literature

Highlights • We expose the clinical relevance of the incorporation of T-DM1 in the treatment of HER2 positive metastatic breast cancer • On the basis of several clinical trials with T-DM1 it is exposed its good safety and tolerability. • We detail the current positioning of T-DM1 in the treatment of HER2 positive breast cancer. • We detail the ongoing clinical trials aiming to position T-DM1 not only in HER2 positive metastatic breast cancer but also in early breast cancer.