Farrerol inhibits IL-6 and IL-8 production in LPS-stimulated human gingival fibroblasts by suppressing PI3K/AKT/NF-κB signaling pathway

Highlights • Farrerol inhibits LPS-induced IL-6 and IL-8 production. • Farrerol inhibits LPS-induced NF-κB activation. • Farrerol inhibits LPS-induced PI3K and Akt phosphorylation.

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Bibliographische Detailangaben
Veröffentlicht in:	Archives of oral biology 2016-02, Vol.62, p.28-32
Hauptverfasser:	Wang, Qian, Zhang, Bin, Yu, Jin-Long
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced Basic Science Anti-Bacterial Agents - pharmacology Anti-Inflammatory Agents - pharmacology Cell Survival - drug effects Cells, Cultured Chromones - pharmacology Dentistry Farrerol Fibroblasts - drug effects Gingiva - cytology Gingiva - drug effects Human gingival fibroblasts Humans IL-6 Interleukin-6 - antagonists & inhibitors Interleukin-6 - biosynthesis Interleukin-8 - antagonists & inhibitors Interleukin-8 - biosynthesis Lipopolysaccharides - pharmacology NF-kappa B - antagonists & inhibitors NF-kappa B - metabolism NF-κB Periodontal Diseases - therapy Phosphatidylinositol 3-Kinases - antagonists & inhibitors Phosphatidylinositol 3-Kinases - metabolism Phosphorylation - drug effects PI3K Signal Transduction - drug effects
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Beschreibung
Zusammenfassung:	Highlights • Farrerol inhibits LPS-induced IL-6 and IL-8 production. • Farrerol inhibits LPS-induced NF-κB activation. • Farrerol inhibits LPS-induced PI3K and Akt phosphorylation.
ISSN:	0003-9969 1879-1506
DOI:	10.1016/j.archoralbio.2015.11.007