Low dose cyclophosphamide: Mechanisms of T cell modulation

Highlights • Regulatory T cells and effector T cells have a differential capacity to detoxify cyclophosphamide metabolites. • Gut microbiota plays an important role in the polarisation of T cells to a Th1 and Th17 phenotype in response to low dose cyclophosphamide. • The duration of drug free interv...

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Veröffentlicht in:	Cancer treatment reviews 2016-01, Vol.42, p.3-9
Hauptverfasser:	Madondo, Mutsa Tatenda, Quinn, Michael, Plebanski, Magdalena
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrolein Acrolein - pharmacology Adenosine Triphosphate - metabolism Animals Antineoplastic Agents, Alkylating - administration & dosage Antineoplastic Agents, Alkylating - pharmacokinetics Antineoplastic Agents, Alkylating - pharmacology Biotransformation Cell Cycle - drug effects Chemotherapy Cross-Linking Reagents - administration & dosage Cross-Linking Reagents - pharmacology Cyclophosphamide Cyclophosphamide - administration & dosage Cyclophosphamide - pharmacokinetics Cyclophosphamide - pharmacology Cytotoxicity, Immunologic - drug effects DNA Damage Dose-Response Relationship, Drug Drug Administration Schedule GSH Hematology, Oncology and Palliative Medicine Humans Neoplasms - drug therapy Neoplasms - immunology Neoplasms - metabolism Neoplasms, Experimental - drug therapy Neoplasms, Experimental - immunology Oxidative Stress Prodrugs - administration & dosage Prodrugs - pharmacokinetics Prodrugs - pharmacology T cells T-Lymphocyte Subsets - drug effects T-Lymphocyte Subsets - immunology T-Lymphocytes, Regulatory - drug effects T-Lymphocytes, Regulatory - immunology
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Zusammenfassung:	Highlights • Regulatory T cells and effector T cells have a differential capacity to detoxify cyclophosphamide metabolites. • Gut microbiota plays an important role in the polarisation of T cells to a Th1 and Th17 phenotype in response to low dose cyclophosphamide. • The duration of drug free intervals affects the efficacy of metronomic low dose cyclophosphamide therapy.
ISSN:	0305-7372 1532-1967
DOI:	10.1016/j.ctrv.2015.11.005