Vitamin D3 enhances bactericidal activity of macrophage against Pseudomonas aeruginosa

The bioactive form of vitamin D3, i.e.1,25-dihydroxyvitamin D3 (1,25(OH)2D3) vitamin D has been shown to modulate monocytes/macrophages physiology and its response against bacterial infections. Pseudomonas aeruginosa (P. aeruginosa) is an opportunistic bacterial pathogen that can most frequently be...

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Veröffentlicht in:	International immunopharmacology 2016-01, Vol.30, p.94-101
Hauptverfasser:	Nouari, Wafa, Ysmail-Dahlouk, Lamia, Aribi, Mourad
Format:	Artikel
Sprache:	eng
Schlagworte:	1,25(OH)2D3 Calcitriol - pharmacology Cell Differentiation - drug effects Cells, Cultured Cytotoxicity, Immunologic - drug effects Gene Expression Regulation - drug effects Humans Interleukin-10 - genetics Interleukin-10 - metabolism Interleukin-1beta - genetics Interleukin-1beta - metabolism Macrophages - drug effects Macrophages - immunology Monocyte-derived macrophages Phagocytosis - drug effects Pseudomonas aeruginosa Pseudomonas aeruginosa - drug effects Pseudomonas aeruginosa - physiology Pseudomonas Infections - immunology Pseudomonas Infections - therapy Receptors, Calcitriol - genetics Receptors, Calcitriol - metabolism Th1 Cells - immunology
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Zusammenfassung:	The bioactive form of vitamin D3, i.e.1,25-dihydroxyvitamin D3 (1,25(OH)2D3) vitamin D has been shown to modulate monocytes/macrophages physiology and its response against bacterial infections. Pseudomonas aeruginosa (P. aeruginosa) is an opportunistic bacterial pathogen that can most frequently be fatal in immunocompromised infected people. We investigated the ex vivo effect of 1,25(OH)2D3 on monocyte-derived macrophages function against P. aeruginosa infection. Relative vitamin D receptor (VDR) mRNA expression was significantly increased in infected and 1,25(OH)2D3-treated macrophages compared to controls (p
ISSN:	1567-5769 1878-1705
DOI:	10.1016/j.intimp.2015.11.033