Immunoglobulin κ gene rearrangements between the κ deleting element and jκ recombination signal sequences in acute lymphoblastic leukemia and normal hematopoiesis

The κ deleting element (κDE) located 24 kb downstream of the Cκ gene segment mediates the deletion of Cκ and the Jκ-Cκ Intron enhancer, which results in allelic exclusion of the immunoglobulin κ light chain locus. We here report that the κDE can recombine to each recombination signal sequence (RSS)...

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Veröffentlicht in:	Leukemia 2000-04, Vol.14 (4), p.671-674
Hauptverfasser:	SERIU, T, HANSEN-HAGGE, T. E, STARK, Y, BARTRAM, C. R
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute lymphoblastic leukemia Acute lymphocytic leukemia Allelic exclusion Biological and medical sciences Care and treatment Cell differentiation, maturation, development, hematopoiesis Cell physiology Fundamental and applied biological sciences. Psychology Gene deletion Genetic aspects Health aspects Hematologic and hematopoietic diseases Hematopoiesis Immunoglobulin genes Immunoglobulins Leukemia Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphatic leukemia Medical sciences Minimal residual disease Molecular and cellular biology Physiological aspects Recombination recombination signal sequence Structure
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Zusammenfassung:	The κ deleting element (κDE) located 24 kb downstream of the Cκ gene segment mediates the deletion of Cκ and the Jκ-Cκ Intron enhancer, which results in allelic exclusion of the immunoglobulin κ light chain locus. We here report that the κDE can recombine to each recombination signal sequence (RSS) flanking Jκ1 to Jκ5 in normal hematopoiesis. Moreover, usage of the JκRSS-κDE junctional sequence allows the detection of minimal residual disease in acute lymphoblastic leukemia.
ISSN:	0887-6924 1476-5551
DOI:	10.1038/sj.leu.2401745