Use of lopinavir/ritonavir in HIV-infected patients failing a first-line protease-inhibitor-containing HAART

Objectives: The long-term virological efficacy of lopinavir/ritonavir-containing highly active antiretroviral therapy (HAART) in HIV-infected patients failing a first-line protease inhibitor (PI)-based regimen is still unclear. Methods: An observational study was carried out from December 2000–Decem...

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Veröffentlicht in:	Journal of antimicrobial chemotherapy 2005-06, Vol.55 (6), p.1003-1007
Hauptverfasser:	Bongiovanni, Marco, Chiesa, Elisabetta, Di Biagio, Antonio, Meraviglia, Paola, Capetti, Amedeo, Tordato, Federica, Cicconi, Paola, Biasi, Patrizia, Bini, Teresa, d'Arminio Monforte, Antonella
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Anti-HIV Agents - administration & dosage Antibiotics. Antiinfectious agents. Antiparasitic agents Antiretroviral Therapy, Highly Active Biological and medical sciences CD4 Lymphocyte Count Drug Therapy, Combination Female genotype resistance HIV Infections - drug therapy HIV Infections - immunology HIV Infections - virology HIV therapy Human immunodeficiency virus Humans Lopinavir LPV/r Male Medical sciences Middle Aged Pharmacology. Drug treatments Pyrimidinones - administration & dosage Ritonavir - administration & dosage RNA, Viral - analysis virological failure
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Zusammenfassung:	Objectives: The long-term virological efficacy of lopinavir/ritonavir-containing highly active antiretroviral therapy (HAART) in HIV-infected patients failing a first-line protease inhibitor (PI)-based regimen is still unclear. Methods: An observational study was carried out from December 2000–December 2002 on 111 consecutive patients starting lopinavir/ritonavir. The primary end-point was virological success (HIV RNA
ISSN:	0305-7453 1460-2091
DOI:	10.1093/jac/dki113