Impact of Preoperative Biliary Drainage on Long-Term Survival in Resected Pancreatic Ductal Adenocarcinoma: A Multicenter Observational Study

Background This study aimed to evaluate the impact of preoperative biliary drainage (PBD) on the long-term survival of patients with pancreatic ductal adenocarcinoma (PDAC) who underwent pancreaticoduodenectomy (PD). Methods A multicenter observational study was performed using a common database of...

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Veröffentlicht in:	Annals of surgical oncology 2015-12, Vol.22 (Suppl 3), p.1238-1246
Hauptverfasser:	Uemura, Kenichiro, Murakami, Yoshiaki, Satoi, Sohei, Sho, Masayuki, Motoi, Fuyuhiko, Kawai, Manabu, Matsumoto, Ippei, Honda, Goro, Kurata, Masanao, Yanagimoto, Hiroaki, Nishiwada, Satoshi, Fukumoto, Takumi, Unno, Michiakil, Yamaue, Hiroki
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Carcinoma, Pancreatic Ductal - mortality Carcinoma, Pancreatic Ductal - secondary Carcinoma, Pancreatic Ductal - surgery Case-Control Studies Cholestasis - etiology Cholestasis - therapy Drainage - methods Endoscopy Female Follow-Up Studies Humans Lymphatic Metastasis Male Medicine Medicine & Public Health Middle Aged Neoplasm Recurrence, Local - mortality Neoplasm Recurrence, Local - pathology Neoplasm Recurrence, Local - surgery Neoplasm Staging Oncology Pancreatectomy - adverse effects Pancreatectomy - mortality Pancreatic Neoplasms - mortality Pancreatic Neoplasms - pathology Pancreatic Neoplasms - surgery Pancreatic Tumors Peritoneal Neoplasms - mortality Peritoneal Neoplasms - secondary Peritoneal Neoplasms - surgery Postoperative Complications Preoperative Care Prognosis Prospective Studies Surgery Surgical Oncology Survival Rate
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Zusammenfassung:	Background This study aimed to evaluate the impact of preoperative biliary drainage (PBD) on the long-term survival of patients with pancreatic ductal adenocarcinoma (PDAC) who underwent pancreaticoduodenectomy (PD). Methods A multicenter observational study was performed using a common database of patients with resected PDAC from seven high-volume surgical institutions in Japan. Results Of 932 patients who underwent PD for PDAC, 573 (62 %) underwent PBD, including 407 (44 %) who underwent endoscopic biliary drainage (EBD) and 166 (18 %) who underwent percutaneous transhepatic biliary drainage (PTBD). The patients who did not undergo PBD and those who underwent EBD had a significantly better overall survival than those who underwent PTBD, with median survival times of 25.7 months ( P
ISSN:	1068-9265 1534-4681
DOI:	10.1245/s10434-015-4618-9