Mannose-binding lectin (MBL) insufficiency protects against the development of systemic inflammatory response after pediatric cardiac surgery

Highlights • MBL2 gene mutations and low MBL concentrations may protect patients from SIRS. • Low MBL-MASP-2 activities may protect from SIRS, LCOS and MOF. • High MBL levels/associated genotypes are risk factors of postoperative complications.

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Immunobiology (1979) 2016-02, Vol.221 (2), p.175-181
Hauptverfasser:	Pągowska-Klimek, Izabela, Świerzko, Anna S, Michalski, Mateusz, Moll, Maciej, Szala-Poździej, Agnieszka, Sokołowska, Anna, Krajewski, Wojciech R, Cedzyński, Maciej
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Advanced Basic Science Allergy and Immunology Cardiac Output - physiology Cardiac Output, Low - etiology Cardiac Output, Low - genetics Cardiac Output, Low - immunology Cardiac Output, Low - pathology Cardiopulmonary bypass (CPB) Cardiopulmonary Bypass - adverse effects Child Child, Preschool Complement Congenital heart disease Female Gene Expression Genotype Humans Immunologic Deficiency Syndromes - blood Immunologic Deficiency Syndromes - genetics Immunologic Deficiency Syndromes - immunology Infant Male Mannan-binding lectin Mannose-binding lectin (MBL) Mannose-Binding Lectin - blood Mannose-Binding Lectin - deficiency Mannose-Binding Lectin - genetics Mannose-Binding Lectin - immunology Mannose-Binding Protein-Associated Serine Proteases - deficiency Mannose-Binding Protein-Associated Serine Proteases - genetics Mannose-Binding Protein-Associated Serine Proteases - immunology Mannose-Binding Protein-Associated Serine Proteases - metabolism Metabolism, Inborn Errors - blood Metabolism, Inborn Errors - genetics Metabolism, Inborn Errors - immunology Postoperative Complications - etiology Postoperative Complications - genetics Postoperative Complications - immunology Postoperative Complications - pathology Prospective Studies Protective Factors Risk Factors SIRS
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Highlights • MBL2 gene mutations and low MBL concentrations may protect patients from SIRS. • Low MBL-MASP-2 activities may protect from SIRS, LCOS and MOF. • High MBL levels/associated genotypes are risk factors of postoperative complications.
ISSN:	0171-2985 1878-3279
DOI:	10.1016/j.imbio.2015.09.010