Taxane Resistance in Prostate Cancer Mediated by AR-Independent GATA2 Regulation of IGF2

GATA2 has been well-characterized as a critical pioneer transcription factor for androgen receptor (AR) in prostate cancer. In this issue of Cancer Cell, Vidal and colleagues identify increased GATA2 and its AR-independent transactivation of IGF2 as a mechanism that can mediate taxane resistance thr...

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Veröffentlicht in:	Cancer cell 2015-02, Vol.27 (2), p.158-159
Hauptverfasser:	Plymate, Stephen R., Bhatt, Rupal S., Balk, Steven P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals GATA2 Transcription Factor - genetics Humans Male Prostatic Neoplasms, Castration-Resistant - drug therapy Prostatic Neoplasms, Castration-Resistant - genetics
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	GATA2 has been well-characterized as a critical pioneer transcription factor for androgen receptor (AR) in prostate cancer. In this issue of Cancer Cell, Vidal and colleagues identify increased GATA2 and its AR-independent transactivation of IGF2 as a mechanism that can mediate taxane resistance through activation of IGF1/insulin receptor signaling. GATA2 has been well-characterized as a critical pioneer transcription factor for androgen receptor (AR) in prostate cancer. In this issue of Cancer Cell, Vidal and colleagues identify increased GATA2 and its AR-independent transactivation of IGF2 as a mechanism that can mediate taxane resistance through activation of IGF1/insulin receptor signaling.
ISSN:	1535-6108 1878-3686
DOI:	10.1016/j.ccell.2015.01.008