BRAF: A Driver of the Serrated Pathway in Colon Cancer

In this issue of Cancer Cell, Rad and colleagues report findings that underscore the importance of oncogenic BRAF mutation coupled with microsatellite instability, p16Ink4a inactivation, and p53 mutation in the serrated pathway of colon cancer development. These findings provide translational insigh...

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Veröffentlicht in:	Cancer cell 2013-07, Vol.24 (1), p.1-2
1. Verfasser:	Rustgi, Anil K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Colonic Neoplasms - etiology Colonic Neoplasms - genetics Genes, p16 Genes, p53 Humans Microsatellite Instability Mutation Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins B-raf - antagonists & inhibitors Proto-Oncogene Proteins B-raf - genetics Proto-Oncogene Proteins p21(ras) ras Proteins - genetics
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Zusammenfassung:	In this issue of Cancer Cell, Rad and colleagues report findings that underscore the importance of oncogenic BRAF mutation coupled with microsatellite instability, p16Ink4a inactivation, and p53 mutation in the serrated pathway of colon cancer development. These findings provide translational insights into potential therapeutic intervention for BRAF mutant colon cancers.
ISSN:	1535-6108 1878-3686
DOI:	10.1016/j.ccr.2013.06.008