Galectin-1 reduced the effect of LPS on the IL-6 production in decidual cells by inhibiting LPS on the stimulation of IκBζ

Highlights • Gal-1 inhibited the induction by LPS of proinflammatory cytokines in decidua cells. • Gal-1 down-regulates IκBζ expression in IL-6 gene transcription. • Treatment of decidua cells with Gal-1 reduced the nuclear translocation of IκBζ. • Gal-1 may contribute to the maintenance of the fetu...

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Veröffentlicht in:	Journal of reproductive immunology 2015-11, Vol.112, p.46-52
Hauptverfasser:	Gómez-Chávez, Fernando, Castro-Leyva, Violeta, Espejel-Núñez, Aurora, Zamora-Mendoza, Rubén G, Rosas-Vargas, Haydee, Cancino-Díaz, Juan C, Cancino-Díaz, Mario E, Estrada-Gutierrez, Guadalupe, Rodríguez-Martínez, Sandra
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Cells, Cultured Decidua - immunology Female Galectin 1 - immunology Galectin-1 Gene Expression Regulation - drug effects Gene Expression Regulation - immunology Humans I-kappa B Proteins - immunology IL-6 Interleukin-6 - immunology IκBζ Lipopolysaccharides - toxicity NF-κB Obstetrics and Gynecology Placenta - immunology Pregnancy Proto-Oncogene Proteins - immunology Transcription, Genetic - drug effects Transcription, Genetic - immunology
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Zusammenfassung:	Highlights • Gal-1 inhibited the induction by LPS of proinflammatory cytokines in decidua cells. • Gal-1 down-regulates IκBζ expression in IL-6 gene transcription. • Treatment of decidua cells with Gal-1 reduced the nuclear translocation of IκBζ. • Gal-1 may contribute to the maintenance of the fetus during gestation.
ISSN:	0165-0378 1872-7603
DOI:	10.1016/j.jri.2015.07.002