Accounting for uncertainty in DNA sequencing data

Accounting for uncertainty in DNA sequencing data

Highlights • We discuss types and sources of uncertainty and error in DNA sequencing data. • We describe the state of uncertainty quantification in DNA sequencing analysis. • Specifying/propagating uncertainties can be done with existing computational tools. • DNA sequencing analyses benefit from ro...

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Veröffentlicht in:Trends in genetics 2015-02, Vol.31 (2), p.61-66
Hauptverfasser: O’Rawe, Jason A, Ferson, Scott, Lyon, Gholson J
Format: Artikel
Sprache:eng
Schlagworte:
Base Sequence
DNA sequencing
High-Throughput Nucleotide Sequencing - methods
High-Throughput Nucleotide Sequencing - standards
Humans
Medical Education
Models, Statistical
Sequence Analysis, DNA - methods
Sequence Analysis, DNA - standards
sequence errors
Uncertainty
uncertainty accounting
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Beschreibung
Zusammenfassung:Highlights • We discuss types and sources of uncertainty and error in DNA sequencing data. • We describe the state of uncertainty quantification in DNA sequencing analysis. • Specifying/propagating uncertainties can be done with existing computational tools. • DNA sequencing analyses benefit from robust and honest uncertainty quantifications.
ISSN:0168-9525
DOI:10.1016/j.tig.2014.12.002