In vitro validation of effects of BDNF-expressing mesenchymal stem cells on neurodegeneration in primary cultured neurons of APP/PS1 mice

Highlights • Efficacy of MSCs on neuronal death. • BDNF-MSCs ameliorated AD pathology. • This was abolished by BDNF-blocking peptides.

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Bibliographische Detailangaben
Veröffentlicht in:	Neuroscience 2015-10, Vol.307, p.37-50
Hauptverfasser:	Song, M.-S, Learman, C.R, Ahn, K.-C, Baker, G.B, Kippe, J, Field, E.M, Dunbar, G.L
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - complications Alzheimer Disease - genetics Alzheimer Disease - pathology Alzheimer’s disease Amyloid beta-Protein Precursor - genetics Animals Apoptosis - genetics bone marrow-derived mesenchymal cells (BM-MSCs) Brain - cytology Brain - metabolism Brain - pathology Brain-Derived Neurotrophic Factor - genetics Brain-Derived Neurotrophic Factor - metabolism brain-derived neurotropic factor (BDNF) Caspase 3 - metabolism Cells, Cultured Coculture Techniques Disease Models, Animal Female Male Mesenchymal Stromal Cells - physiology Mice Mice, Inbred C57BL Mice, Transgenic Mutation - genetics Nerve Tissue Proteins - metabolism neurodegeneration Neurodegenerative Diseases - etiology Neurodegenerative Diseases - pathology Neurology Neurons - metabolism Presenilin-1 - genetics β-amyloid (Aβ)
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Beschreibung
Zusammenfassung:	Highlights • Efficacy of MSCs on neuronal death. • BDNF-MSCs ameliorated AD pathology. • This was abolished by BDNF-blocking peptides.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2015.08.011