Serotonin in the dorsal periaqueductal gray inhibits panic-like defensive behaviors in rats exposed to acute hypoxia

Highlights • Hypoxia-evoked escape in a model of respiratory-type panic attacks. • Dorsal periaqueductal gray harbors a hypoxia-sensitive suffocation alarm system. • dPAG-serotonergic neurotransmission impairs escape reactions evoked by severe hypoxia.

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Bibliographische Detailangaben
Veröffentlicht in:	Neuroscience 2015-10, Vol.307, p.191-198
Hauptverfasser:	Spiacci, A, de Oliveira Sergio, T, da Silva, G.S.F, Glass, M.L, Schenberg, L.C, Garcia-Cairasco, N, Zangrossi, H
Format:	Artikel
Sprache:	eng
Schlagworte:	Alprazolam - pharmacology Analysis of Variance Animals Defense Mechanisms Dose-Response Relationship, Drug GABA Modulators - pharmacology hypoxia Hypoxia - complications Hypoxia - pathology Male Microinjections Neurology Panic - physiology periaqueductal gray Periaqueductal Gray - drug effects Periaqueductal Gray - metabolism Rats Rats, Wistar respiratory panic serotonin Serotonin - metabolism Serotonin Agents - pharmacology
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Beschreibung
Zusammenfassung:	Highlights • Hypoxia-evoked escape in a model of respiratory-type panic attacks. • Dorsal periaqueductal gray harbors a hypoxia-sensitive suffocation alarm system. • dPAG-serotonergic neurotransmission impairs escape reactions evoked by severe hypoxia.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2015.08.045