Neutralizing antibody and functional mapping of Bacillus anthracis protective antigen—The first step toward a rationally designed anthrax vaccine

Highlights • Rational antigens focus immune responses to defined pathogen neutralizing epitopes. • Current anthrax vaccines have pitfalls that may be overcome by rational antigens. • Neutralizing epitopes and functional maps provide rational vaccine targets.

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Bibliographische Detailangaben
Veröffentlicht in:	Vaccine 2016-01, Vol.34 (1), p.13-19
Hauptverfasser:	McComb, Ryan C, Martchenko, Mikhail
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Aluminum Amino acids Anthrax Anthrax Vaccines - immunology Anthrax Vaccines - isolation & purification Antibodies, Bacterial - immunology Antibodies, Neutralizing - immunology Antigens Antigens, Bacterial - genetics Antigens, Bacterial - immunology Antigens, Bacterial - metabolism Antitoxins - immunology Bacillus anthracis Bacterial Toxins - genetics Bacterial Toxins - immunology Bacterial Toxins - metabolism Design DNA Mutational Analysis Epitope Mapping Functional mapping Humans Immunoglobulins Mortality Mutagenesis Neutralizing antibody mapping Pathogenesis Pathogens Prevention Protective antigen Rational vaccine design Studies Toxins Vaccines
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Beschreibung
Zusammenfassung:	Highlights • Rational antigens focus immune responses to defined pathogen neutralizing epitopes. • Current anthrax vaccines have pitfalls that may be overcome by rational antigens. • Neutralizing epitopes and functional maps provide rational vaccine targets.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2015.11.025