Quantification of viral genome in cord blood donors by real time PCR to investigate human herpesvirus type 8 active infection

Abstract Umbilical cord blood (UCB) is one of the most important sources of hematopoietic stem cells which can be used for transplantation. The transplanted CB stem cells might cause infections in recipients. The aim of this study is to evaluate Human Herpes Virus8 (HHV8) as a Rhadinovirus among CB...

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Veröffentlicht in:	Transfusion and apheresis science 2015-12, Vol.53 (3), p.378-380
Hauptverfasser:	Golchin, Neda, Kheirandish, Maryam, Sharifi, Zohreh, Samiee, Shahram, Kokhaei, Parviz, Pourpak, Zahra
Format:	Artikel
Sprache:	eng
Schlagworte:	Blood Donors Cord blood Cord Blood Stem Cell Transplantation Female Fetal Blood - virology Genome, Viral Health technology assessment Hematology, Oncology and Palliative Medicine Herpesvirus 8, Human HHV8 Humans Leukocytes, Mononuclear - virology Male Real time PCR Real-Time Polymerase Chain Reaction - methods
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Zusammenfassung:	Abstract Umbilical cord blood (UCB) is one of the most important sources of hematopoietic stem cells which can be used for transplantation. The transplanted CB stem cells might cause infections in recipients. The aim of this study is to evaluate Human Herpes Virus8 (HHV8) as a Rhadinovirus among CB samples in order to assess safety of cord blood stem cells transplantation. To assess this aim, we surveyed 800 cord blood specimens by Real Time PCR.The overall HHV8 incidence in cord blood mononuclear cells was 1.38% and none of them was in lytic phase of HHV8. The authors suggest further HHV8 study on CB samples for transplantation.
ISSN:	1473-0502 1878-1683
DOI:	10.1016/j.transci.2015.08.001