CD4+ T cell counts in initiation of antiretroviral therapy in HIV infected asymptomatic individuals; controversies and inconsistencies

Highlights • Assesses available data on optimal time to initiate therapy in HIV-infected asymptomatic individuals with respect to CD4+ T cell threshold. • Discuss arguments for and against early or late initiation of ART. • Discusses available information from 1998 through 2015. • Presents authors c...

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Veröffentlicht in:	Immunology letters 2015-12, Vol.168 (2), p.279-284
Hauptverfasser:	Maina, E.K, Bonney, E.Y, Bukusi, E.A, Sedegah, M, Lartey, M, Ampofo, W.K
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS Allergy and Immunology Anti-HIV Agents - therapeutic use Antiretroviral therapy CD4 Lymphocyte Count CD4+ T cell Europe HIV HIV - drug effects HIV - immunology HIV - physiology HIV Infections - drug therapy HIV Infections - immunology HIV Infections - virology Humans Practice Guidelines as Topic Time Factors United States World Health Organization
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Beschreibung
Zusammenfassung:	Highlights • Assesses available data on optimal time to initiate therapy in HIV-infected asymptomatic individuals with respect to CD4+ T cell threshold. • Discuss arguments for and against early or late initiation of ART. • Discusses available information from 1998 through 2015. • Presents authors conclusion and views.
ISSN:	0165-2478 1879-0542
DOI:	10.1016/j.imlet.2015.10.005