TGR5 and Immunometabolism: Insights from Physiology and Pharmacology

In the past decade substantial progress has been made in understanding how the insurgence of chronic low-grade inflammation influences the physiology of several metabolic diseases. Tissue-resident immune cells have been identified as central players in these processes, linking inflammation to metabo...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Trends in pharmacological sciences (Regular ed.) 2015-12, Vol.36 (12), p.847-857
Hauptverfasser:	Perino, Alessia, Schoonjans, Kristina
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced Basic Science Animals bile acids Bile Acids and Salts - metabolism Bile Acids and Salts - pharmacology Humans inflammation Inflammation - drug therapy Inflammation - immunology Inflammation - metabolism macrophages metabolism Receptors, G-Protein-Coupled - agonists Receptors, G-Protein-Coupled - immunology Receptors, G-Protein-Coupled - metabolism Receptors, G-Protein-Coupled - physiology TGR5
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	In the past decade substantial progress has been made in understanding how the insurgence of chronic low-grade inflammation influences the physiology of several metabolic diseases. Tissue-resident immune cells have been identified as central players in these processes, linking inflammation to metabolism. The bile acid-responsive G-protein-coupled receptor TGR5 is expressed in monocytes and macrophages, and its activation mediates potent anti-inflammatory effects. Herein, we summarize recent advances in TGR5 research, focusing on the downstream effector pathways that are modulated by TGR5 activators, and on its therapeutic potential in inflammatory and metabolic diseases.
ISSN:	0165-6147 1873-3735
DOI:	10.1016/j.tips.2015.08.002