Outcomes in Relapsed Graves' Disease Patients Following Radioiodine or Prolonged Low Dose of Methimazole Treatment

Background: Low doses of antithyroid drugs (ATD) for extended periods may be an alternative for Graves' disease (GD) patients who relapse after a course of ATD. Methods: Patients with GD relapse ( n  = 238) after discontinuation of ATD therapy for 12–24 months were retrospectively analyzed in a...

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Veröffentlicht in:Thyroid (New York, N.Y.) N.Y.), 2015-12, Vol.25 (12), p.1282-1290
Hauptverfasser: Villagelin, Danilo, Romaldini, João H., Santos, Roberto B., Milkos, Ana B.B.P., Ward, Laura S.
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Sprache:eng
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Zusammenfassung:Background: Low doses of antithyroid drugs (ATD) for extended periods may be an alternative for Graves' disease (GD) patients who relapse after a course of ATD. Methods: Patients with GD relapse ( n  = 238) after discontinuation of ATD therapy for 12–24 months were retrospectively analyzed in a nonrandomized study. Radioiodine (RAI) treatment and L-thyroxine replacement was used in 114 patients, and a low dose of methimazole (MMI; 2.5–7 mg/daily) was used in 124 patients. Thyroid dysfunction, Graves' ophthalmopathy (GO) evolution, quality of life (QoL), and body weight were evaluated during the follow-up. Results: The mean follow-up was 80.8 ± 35.3 months for the RAI group, and 71.3 ± 40.3 months for the low-dose MMI group. No notable side effects were observed in either group. Thyroid dysfunction was predominant in the RAI group ( p  
ISSN:1050-7256
1557-9077
DOI:10.1089/thy.2015.0195