The History of Target-Controlled Infusion

Target-controlled infusion (TCI) is a technique of infusing IV drugs to achieve a user-defined predicted (“target”) drug concentration in a specific body compartment or tissue of interest. In this review, we describe the pharmacokinetic principles of TCI, the development of TCI systems, and technica...

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Veröffentlicht in:	Anesthesia and analgesia 2016-01, Vol.122 (1), p.56-69
Hauptverfasser:	Struys, Michel M. R. F., De Smet, Tom, Glen, John (Iain) B., Vereecke, Hugo E. M., Absalom, Anthony R., Schnider, Thomas W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthetics, Intravenous - administration & dosage Anesthetics, Intravenous - adverse effects Anesthetics, Intravenous - blood Anesthetics, Intravenous - history Anesthetics, Intravenous - pharmacokinetics Consciousness - drug effects Drug Delivery Systems - history Drug Delivery Systems - instrumentation Drug Dosage Calculations Drug Monitoring - history Equipment Design History, 20th Century History, 21st Century Humans Hypnotics and Sedatives - administration & dosage Hypnotics and Sedatives - adverse effects Hypnotics and Sedatives - blood Hypnotics and Sedatives - history Hypnotics and Sedatives - pharmacokinetics Infusions, Intravenous Models, Biological Monitoring, Intraoperative - history Software
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