The History of Target-Controlled Infusion

Target-controlled infusion (TCI) is a technique of infusing IV drugs to achieve a user-defined predicted (“target”) drug concentration in a specific body compartment or tissue of interest. In this review, we describe the pharmacokinetic principles of TCI, the development of TCI systems, and technica...

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Veröffentlicht in:	Anesthesia and analgesia 2016-01, Vol.122 (1), p.56-69
Hauptverfasser:	Struys, Michel M. R. F., De Smet, Tom, Glen, John (Iain) B., Vereecke, Hugo E. M., Absalom, Anthony R., Schnider, Thomas W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthetics, Intravenous - administration & dosage Anesthetics, Intravenous - adverse effects Anesthetics, Intravenous - blood Anesthetics, Intravenous - history Anesthetics, Intravenous - pharmacokinetics Consciousness - drug effects Drug Delivery Systems - history Drug Delivery Systems - instrumentation Drug Dosage Calculations Drug Monitoring - history Equipment Design History, 20th Century History, 21st Century Humans Hypnotics and Sedatives - administration & dosage Hypnotics and Sedatives - adverse effects Hypnotics and Sedatives - blood Hypnotics and Sedatives - history Hypnotics and Sedatives - pharmacokinetics Infusions, Intravenous Models, Biological Monitoring, Intraoperative - history Software
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Beschreibung
Zusammenfassung:	Target-controlled infusion (TCI) is a technique of infusing IV drugs to achieve a user-defined predicted (“target”) drug concentration in a specific body compartment or tissue of interest. In this review, we describe the pharmacokinetic principles of TCI, the development of TCI systems, and technical and regulatory issues addressed in prototype development. We also describe the launch of the current clinically available systems.
ISSN:	0003-2999 1526-7598
DOI:	10.1213/ANE.0000000000001008