Skeletal Muscle Response to Endurance Training in IL-6−/− Mice

Abstract We examined effects of moderate-intensity endurance training on muscle COX/CS activities and V’O 2max in control WT and IL-6 −/− mice. Animals were exercised for 10 weeks on treadmill for 1 h, 5 days a week at velocity of 6 m·min −1 which was increased by 0.5 m·min −1 every 2 weeks up to 8 m·min −1 . Training triggered an increase of enzyme activities in soleus muscle of WT mice (COX: 480.3±8.9 U·g −1 in sedentary group vs. 773.3±62.6 U·g −1 in trained group, P